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Year Course ID Course
2021-2022 BIOT 100

Biotechnology Practicum I

This hands-on course is part of an intern program in the Biology Department at TWU designed to provide instruction in general laboratory procedures and laboratory safety beyond that required during regular undergraduate laboratories. Performed tasks are evaluated and occur in the areas of animal husbandry, general laboratory maintenance, cell culture, histochemistry, light microscopy, and protein chemistry (i.e. western blotting, SDS-PAGE). Students will also acquire general instruction in Good Laboratory Practice (GLP) and Good Animal Practice (GAP).

Course Credits: 1
Prerequisite(s): BIOL 103, 104, 105 or BIOL 113, 114.
Co-requisite(s): BIOL 103, 104, 105 or BIOL 113, 114
2021-2022 BIOT 200

Biotechnology Practica II

Biotechnology Practica II-IV provide general and advanced intern experiences in industrial settings. BIOT 200 (2 sem. hrs.) is a requirement for entry to co-op placements and graduation. BIOT 300 and 400 (3 sem. hrs. each) are additional intern experiences providing exposure to advanced techniques and applications in biotechnology. The skills taught in each practicum vary depending on the industrial setting, but should include some of the following techniques: mammalian tissue culture; monoclonal antibody production including cell fusion; hybridoma screening by ELISA and immunoblotting; fermentation microbiology and the operation of large-scale fermentation systems; insect cell culture and use of Baculovirus expression vectors to produce recombinant proteins; downstream processing and the recovery and purification of proteins, carbohydrates, lipids; freezing, freeze-drying and preservation of microorganisms, animal viruses, cell lines and hybridomas; high throughput screening strategies, diagnostic testing; methods in bioinformatics; and quality control procedures.

Course Credits: 2, 3
Prerequisite(s): BIOT 100.
Cross-listed: BIOL 200, 300
2021-2022 BIOT 290

Introduction to Biotechnology

This course reviews the role of modern biotechnology in plant, animal, and marine biology, microbiology, agriculture, the pharmaceutical industry and medicine. The course focuses on underlying technologies in biotechnology, how these technologies are implemented, together with public concerns and government guidelines and legislation.

Course Credits: 3
Prerequisite(s): BIOL 103, 104, and 105 or BIOL 113, 114.
Cross-listed: BIOL 290
2021-2022 BIOT 300

Biotechnology Practica III

Biotechnology Practica II-IV provide general and advanced intern experiences in industrial settings. BIOT 200 (2 sem. hrs.) is a requirement for entry to co-op placements and graduation. BIOT 300 and 400 (3 sem. hrs. each) are additional intern experiences providing exposure to advanced techniques and applications in biotechnology. The skills taught in each practicum vary depending on the industrial setting, but should include some of the following techniques: mammalian tissue culture; monoclonal antibody production including cell fusion; hybridoma screening by ELISA and immunoblotting; fermentation microbiology and the operation of large-scale fermentation systems; insect cell culture and use of Baculovirus expression vectors to produce recombinant proteins; downstream processing and the recovery and purification of proteins, carbohydrates, lipids; freezing, freeze-drying and preservation of microorganisms, animal viruses, cell lines and hybridomas; high throughput screening strategies, diagnostic testing; methods in bioinformatics; and quality control procedures.

Course Credits: 2, 3
Prerequisite(s): BIOT 100.
Cross-listed: BIOL 200, 300
2021-2022 BIOT 390

Biotechnology & Christian Theology

This course is designed to untangle some of the actual or perceived dissonance between issues of biological science and Christian theology. Six major topics are addressed: (1) models, analogies and metaphors in science and Christian theology; (2) scientific and religious investigations of the biosphere; (3) defining human nature; (4) defining non-human nature; (5) caring for the earth; and (6) the biomedical revolution. The common threads among these topics are the tension between Christian faith and the findings of basic and applied biology (biotechnology), and the call to action required in a faith-based view of creation. As well as speaking from their own disciplines and background, the course instructors take part in panel discussions at the end of each of the six units to foster discussion and dialogue on the issues. Student participation is further encouraged by group projects in which the group must develop and dissonance between scientific and religious worldview perspectives.

Course Credits: 3
Prerequisite(s): BIOL 103, 104, and 105 or BIOL 113, 114; third year standing.
NB: Not offered every year See department chair
Cross-listed: BIOL 390.
2021-2022 BIOT 400

Biotechnology Practica IV

Biotechnology Practica II-IV provide general and advanced intern experiences in industrial settings. BIOT 200 (2 sem. hrs.) is a requirement for entry to co-op placements and graduation. BIOT 300 and 400 (3 sem. hrs. each) are additional intern experiences providing exposure to advanced techniques and applications in biotechnology. The skills taught in each practicum vary depending on the industrial setting, but should include some of the following techniques: mammalian tissue culture; monoclonal antibody production including cell fusion; hybridoma screening by ELISA and immunoblotting; fermentation microbiology and the operation of large-scale fermentation systems; insect cell culture and use of Baculovirus expression vectors to produce recombinant proteins; downstream processing and the recovery and purification of proteins, carbohydrates, lipids; freezing, freeze-drying and preservation of microorganisms, animal viruses, cell lines and hybridomas; high throughput screening strategies, diagnostic testing; methods in bioinformatics; and quality control procedures.

Course Credits: 2, 3
Prerequisite(s): BIOT 100.
Cross-listed: BIOL 200, 300
2021-2022 BIOT 409

Thesis Preparation

Students will be required to choose a topic for their senior thesis (BIOL 409-410/GENV 409- 410) in consultation with an instructor. Selected readings and references pertinent to the topic will be assigned. A final written report will be presented consisting of a detailed thesis proposal and a review of the literature.

Course Credits: 1
Prerequisite(s): Advanced standing in biotechnology. (1-1; 0-0)
Cross-listed: BIOL 409
2021-2022 BIOT 410

Senior Thesis

Research in a chosen area of biology or environmental studies with a final written report. Presentation of research findings will also be made by the student in a poster session.

Course Credits: 2
Prerequisite(s): BIOL 409, a related directed study in preparation, or instructor's consent. (0-0; 1-2)
Cross-listed: BIOL 410
2021-2022 BIOT 470

Introduction to Bioinformatics

An overview of the interdisciplinary science of genomics, proteomics, and bioinformatics which applies the tools of information technology (computer hardware and software) to analyze biological data such as gene or protein sequences. This course examines the theory of bioinformatics as well as its practical application to biological problems using approaches such as BLAST searches, phylogenetics, and protein structure function analysis.

Course Credits: 3
Prerequisite(s): BIOL 223; BIOL/CHEM 372; and either 3 sem. hrs. of computing science or MATH 102. (0-0; 3-3-0)
NB: Not offered every year. See department chair.
Cross-listed: BIOL 470 or CMPT 470
2021-2022 BIOT 490

Advanced Biotechnology

This capstone course in biotechnology considers the theoretical and practical aspects of implementing biotechnology, paying particular attention to current issues including: (1) technology transfer and commercialization; (2) patent protection in biotechnology; (3) Good Laboratory Practices (GLP); (4) Good Manufacturing Practices (Food and Drug Regulations, 2002 edition); (5) Good Clinical Practices (GCP); (6) Research Ethics Board guidelines; (7) validation studies; (8) downstream processing and the recovery of purified products; (9) novel developments in methodology. The course includes a seminar series by industry and regulatory experts and site visits to local biotechnology companies to assess how they have implemented and overcome obstacles to production and quality control.

Course Credits: 3
Prerequisite(s): BIOL 223; BIOL 372, And either 3 sem. hrs. of Computing Science or MATH 102. (0-0; 3-3)
Cross-listed: BIOL 490