Associate Professor of Biology and Director of Biotechnology
Office
Neufeld Science Centre
Phone
+1 (604) 513-2121 ext. 3257

Department(s) or Program(s)

Research & Scholarship

Education

B.Sc.H. (Biology), Queen's University, 1987.
M.Sc. (Pharmacology and Toxicology), Queen's University, 1992.
Ph.D. (Neuroscience), University of British Columbia, 1998.

Awards & Honors

  • Murdock Murdock College Research Program for Life Sciences Award (2013-2015)
  • Murdock College Research Program for Life Sciences Award (2011-2013)
  • Internal Research Award, Trinity Western University (2010)
  • Internal Research Award, Trinity Western University (2010)
  • Diabetes Research Endowment Fund, Trinity Western University (2009)
  • Medical Research Council Post-Doctoral Fellowship, University of British Columbia (2000 – 2002)
  • Medical Research Council Post-Doctoral Fellowship, University of Toronto (1999 – 2000)
  • Alzheimer Society of Ontario Post-Doctoral Fellow Award, University of Toronto (1998 – 1999)
  • Alzheimer Society of Canada Doctoral Award, University of British Columbia (1993 – 1997)
  • Graduate Student Travel Fund, University of British Columbia (1993 – 1994)
  • Friends of the Scottish Society Award, Queen’s University (1989 – 1991)
  • Eldon Boyd Fellowship, Queen’s University 
  • Leonard Foundation Award, Queen’s University

 

Recent Publications

Sikkema K.A. W., Strikwerda A., Assi K., Salh B. and Mills J.(2013) Regulation of Mitotic Cytoskeleton Dynamics and Cytokinesis by Integrin-Linked Kinase in Retinoblastoma Cells (Accepted with revisions to PLoS One)

Gasgonia J., Digicaylioglu M., Oloumi A., Seigel G.M., Dedhar and Mills J. (2011) Insulin Attenuates Apoptosis in Neuronal Cells by an Integrin-Linked Kinase-Dependent Mechanism. (Accepted with revisions to PloS One)

McDonald P. C., Oloumi A., Mills J., Dobreva I., Maidan M., Gray V., Wederell E. D., Bally M. B., Foster L. J., and Dedhar S. (2008) Rictor and Integrin-Linked Kinase Interact and Regulate AKT Phosphorylation and Cancer Cell Survival. Cancer Res. 68, 1618-1624.

Assi K., Mills J., Owen D., Ong C., St. Arnaud R., Dedhar S., and Salh B. (2008).Integrin-Linked Kinase Regulates Cell Proliferation and Tumour Growth in Murine Colitis-Associated Carcinogenesis. Gut 57, 931-940.

Mills J., Oloumi A., Mawji N.M., Wilson J., Rico B., Reichardt L.F., and Dedhar S. (2006) Integrin-Linked Kinase is Critical for Cerebellar Granule Cell Precursor Proliferation. J. Neurosci. 26, 830-840.

Niewmierzycka A., Mills J., St-Arnaud R., Dedhar S., and Reichardt L.F. (2005) Integrin Linked Kinase (ILK) Deletion From Mouse Cortex Results In Cortical Lamination Defects Resembling Cobblestone Lissencephaly. J Neurosci. 25, 7022-31.

Attwell S., Mills J., Troussard A., Wu C., and Dedhar S. (2003) Integration of Cell Attachment , Cytoskeletal Localization, and Signaling by Integrin-Linked Kinase (ILK), CH-ILKBP, and Tumor Suppressor PTEN. Mol. Biol. Cell 14, 4813-4825.

Mills J., Digicaylioglu M., Legg A.T., Young C.E., Young S.S., Barr A.M., Fletcher L., O'Connor T.P., and Dedhar S. (2003) Role of Integrin-Linked Kinase in Nerve Growth Factor-Stimulated Neurite Outgrowth. J. Neurosci. 23, 1638-1648.

Chen F., Yang D.-S., Pentanceska S., Yang A., Tandon A., Yu G., Rozmahel R., Ghiso J., Nishimura M., Zhang D.M., Kawarai T., Levesque G., Mills J., Levesque L., Song Y.-Q., Rogaeva E., Westaway D., Mount H., Gandy S., St. George-Hyslop P. and Fraser P.E. (2000) Carboxyl-terminal fragments of Alzheimer β-Amyloid Precursor Protein Accumulate in Restricted and Unpredicted Intracellular Compartments in Presenilin 1-Deficient Cells. J.B.C. 275, 36794-36802.

Mills J. and Reiner P.B. (1999) MAPK is Involved in NMDA Receptor Regulation of APP Cleavage. Neurosci. 94, 1333-1338.

Mills J. and Reiner P.B. (1999) Regulation of Amyloid Precursor Protein Cleavage. J. Neurochem. 72, 443-460.

Mills J., Charest D.L., Lam F., Beyreuther K., Ida N., Pelech S.L. and Reiner P.B. (1997) Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway. J Neurosci. 17, 9415-9422.

Mills J. and Reiner P.B. (1996) Phorbol esters but not the cholinergic agonists oxotremorine-M and carbachol increase release of the amyloid precursor protein in cultured rat cortical neurons. J Neurochem. 67, 1511-1518.

Expertise

Cell Signalling, Alzheimer’s Disease, Stem Cell Research, Cancer Biology

Courses Taught

Biotechnology Practicum I (BIOT 100)
Biotechnology Practica II, III, IV (BIOT 200/300/400)
Introduction to Biotechnology (BIOT 290)
Human Histology (BIOL 343)
Vertebrate Physiology (BIOL 345)
Biotechnology and Christian Theology (BIOT 390)
Advanced Biotechnology (BIOT 490)