This course examines leadership approaches to innovation and organizational change in environments shaped by artificial intelligence (AI) and rapid technological transformation. The course explores how innovation systems are designed and sustained through strategy, structure, culture, and governance, and how AI adoption reshapes organizational capabilities, work practices, and leadership responsibilities. Emphasis is placed on innovation portfolio management, enterprise-level AI adoption, workforce impact, resistance to change, and ethical leadership. The course also considers stewardship, human dignity, and the application of a Christian worldview in aligning innovation and AI strategies with effective organizational change and long-term performance.